Molecular Toxicology of Organophosphate Poisoning

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, increase the fulfillment population's consumption needs has a double-edged sword effect, on one hand it can need for food be consumed by population. negative effect that arise is safety organophosphate drugs which contaminate soil water sources around place where are used. effects associated with xenobiotics humans who consume them. Xenobiotics toxicdynamic cause irreversible inhibition enzyme acetylcholinesterase (ACh). ACh main enzymes in nervous system terminates impulse conduction through hydrolysis process acetylcholine enzymes. Acetylcholinesterase specific molecular target pesticides. Ach causes normally always hydrolyzed biological marker pesticide poisoning. Inhibition will accumulation acetylcholine, resulting poisoning lead death. In this paper, authors collect from various related study toxicology toxidynamic drug results review article show death individual concerned.